Jun 14, 2025
8
mins read
The Axiom-4 mission (Ax-4) is a private astronaut flight to the International Space Station (ISS) operated by Texas-based Axiom Space using SpaceX’s Crew Dragon spacecraft. On June 25, 2025 at 2:31 a.m. ET, the Ax-4 crew launched from Launch Complex 39A at NASA’s Kennedy Space Center on a Falcon 9 rocket. The 2nd stage of Falcon 9 had flown before, and the Dragon capsule (Endeavour) previously flew Ax-2. This mission makes Shubhanshu Shukla (IAF/ISRO) the second Indian in space (after Rakesh Sharma in 1984) and the first Indian to ever visit the ISS. Veteran NASA astronaut Peggy Whitson (now an Axiom VP for human spaceflight) commands the flight, with Shukla as pilot. After docking on June 26, the crew will spend about 14 days on the ISS conducting roughly 60 experiments across 31 countries. This launch finally broke a string of delays (due to weather and a LOX leak on Falcon 9 and a pressure leak in the ISS Zvezda module) that had postponed earlier launch dates in early June.
Launch Site: Kennedy Space Center LC-39A (the historic Apollo/SpaceX pad) will be the launch site for the Axiom 4 mission.
Launch Vehicle: SpaceX Falcon 9 rocket (with a reused 1st stage) carrying the Crew Dragon Endeavour.
Crew (4 members): Commander Peggy Whitson (USA), Pilot Shubhanshu Shukla (India), Mission Specialist Sławosz Uznanski (Poland), and Mission Specialist Tibor Kapu (Hungary). All three non‑US crew members are national firsts on the ISS. Whitson, an ex-NASA astronaut, brings 665+ days in space to the mission.
Mission Duration: About 14 days docked to the ISS. (Ax-4 is a short-duration charter flight; docking is set for June 26, with departure roughly two weeks later.)
Launch Date: June 25, 2025 (after earlier slips); originally planned for June 10–11 but postponed due to technical issues.
India’s Contribution: The Government of India is funding Shukla’s training and experiments (≈₹550 crore allocated). India provided 7 experiments for microgravity research (biology, biotechnology, human-computer interaction, etc.) to fly on Ax-4.
Strategic Origin: Ax-4 fulfills a pledge by PM Modi and President Biden (2023) to send an Indian to the ISS, aligning with India’s Artemis Accords commitment (as 27th signatory) to international space cooperation.
Table of content
Crew of axiom-4 (Axiom Mission 4): Commander & Pilot
Commander: Peggy Whitson
Position & Role
Director of Human Spaceflight at axiom space
Mission commander for axiom-4, tasked with overall leadership
Space Credentials
Mission Launch

Pilot: Group Captain Shubhanshu Shukla
Background & Training
Role on axiom-4
Indian Spaceflight Firsts
Additional Crew Members
The Ax-4 mission is research‑intensive. Indian and Axiom announcements list ~60 experiments and demos (the largest suite in any Axiom mission so far).
Key Indian payloads were part of Axiom 4 Mission (Ax-4), which involved scientific experiments aboard the ISS.
International Space Station (ISS): All Ax-4 experiments were conducted aboard the International Space Station, following its biosafety and ethics review protocols.
ISRO: These experiments mark India's growing role in space biosciences, coordinated in part by ISRO.
The Axiom‑4 (also known as Ax‑4, Axiom Mission 4) represents a major leap in commercial scientific exploration aboard the International Space Station (ISS). This private mission by Axiom Space launched via SpaceX launches on a reused Falcon 9 launch from Kennedy Space Center’s LC‑39A. It features a comprehensive suite of research payloads curated by India, reflecting the nation’s emerging leadership in microgravity biology.
Key Indian Payloads
Microgravity biology & life‑support studies:
Plant growth experiments: Multiple crop varieties, such as fenugreek (methi) and moong daal, are being cultivated in space to test sustainable food production—a vital component in long-duration missions.
Biotechnology: Research includes protein crystallization and microbial studies aimed at advancing biomedical science.
Human factors: Cognitive performance is being evaluated through on‑screen tests (“Screens in Space”), exploring how astronauts interact with displays in microgravity.

Tardigrades (water bears):
The Indian-led Voyager Tardigrades experiment, flying on Ax‑4, sends hardy microscopic organisms to the ISS to study survival, revival, reproduction, and gene expression in space.
Tardigrades are renowned for their resilience in extreme environments, making them ideal for testing biological hardiness in microgravity.
Purpose of the Research
Dual goals: The Axiom mission supports both near‑term scientific outcomes (like insights into plant growth and human-computer interaction) and long-term capacity building, laying groundwork for India’s planned space‑bio labs.
Educational & ethical compliance: All experiments onboard Axiom‑4 adhere to ISS biosafety and ethics review standards. Indian crews and payloads are regulated by both ISS guidelines and emerging Indian "space biology" ethics frameworks.
Strategic alignment: Insights from these payloads feed directly into Gaganyaan preparations—India's indigenous crewed mission—and future Falcon Heavy, Falcon 9 launches, and private station plans.
Why Tardigrades Matter on Axiom‑4
Model organism in space science: Tardigrades, often dubbed “water bears,” are microscopic extremophiles capable of cryptobiosis. The Voyager Tardigrades payload aboard Axiom Mission 4 examines their survival under space conditions—radiation, vacuum, temperature extremes—which holds promise for biotechnology and astronaut protection.
Molecular insights & space durability: By analyzing gene expression variations between space-flown and Earth-bound tardigrades, researchers aim to decode mechanisms behind DNA repair and stress resilience, knowledge critical for long-duration missions aboard Falcon 9 launch vehicles and private stations.
India’s scientific diplomacy: The Axiom‑4 mission, powered by Axiom Space and SpaceX launches, demonstrates India’s capacity to lead credible space science via public–private and international cooperation.
Compliance and Implementation
Biosafety & ethics: Indian and global researchers ensured ISS-standard biosafety protocols govern these experiments.
Policy significance: Data on tardigrades, plants, microbes, and human-computer interaction in microgravity will guide India’s regulatory and ethical blueprint for future space missions—especially relating to insurance, liability, and independent payload handling.
Ax-4 is the most international Axiom flight yet: it’s the first time three countries are debuting on station together. It also has the largest science payload (~60 experiments) and includes the first Axiom crew member who will later command a national program (Shukla & Gaganyaan). Unlike Ax-1/2/3 (which included space tourists or mission specialists), Ax-4 is explicitly framed as “realizing the return” of these nations to space exploration. NASA’s involvement (peer-reviewed ISS science, docking with Expedition crew) is greater, highlighting the mission’s collaborative nature.
For context, here is a comparative table for India, China, and the USA in human spaceflight:
Category | India | China | USA |
First Citizen in Space | 1984 – Rakesh Sharma (via India–USSR cooperation) | 2003 – Yang Liwei (Shenzhou 5) | 1961 – Alan Shepard (Mercury-Redstone 3) |
Indigenous Crew Vehicle | Planned – LVM3 Crew module (~2027) | Operational – Shenzhou (since 2003) | Operational – Crew Dragon (2019), Boeing Starliner (~2025) |
Space Station Operations | Planned – Own station by 2035 | Operational – Tiangong Station | Operational – ISS (1998–present), Axiom Station post-2030 |
Commercial Human Spaceflight | Ax-4 seat (first Indian private astronaut in space) | None – Fully state-controlled | Active – Multiple SpaceX missions (9+), Boeing missions upcoming |
International Collaboration | Multilateral – Partnerships with US, Russia, EU | Limited – Primarily self-reliant | Extensive – ISS with global partners, robust private ecosystem |
Axiom Mission 4, or Ax-4, also raises significant policy questions for India and other emerging space nations:
Space Debris / Liability:
The Crew Dragon capsule (launched via Falcon 9 launch by SpaceX launches) jettisons its trunk, which burns up during reentry, producing controlled debris.
Under the Liability Convention and India’s draft space law, the launching state or company (e.g., Axiom Space or SpaceX) may be held responsible for damage caused by such debris.
Axiom Mission 4 serves as a live case to help India frame insurance and liability norms for future commercial human spaceflights.
Equitable Access:
Private seat sales, like those offered in Axiom Mission flights, can reduce costs through public funds, philanthropy, or partnerships.
However, this model may favor wealthier nations or institutions, making access unequal.
Countries like India, Poland, and Hungary often depend on partner-provided seats rather than independent missions, raising concerns over equity in global spaceflight.
Biomedical Ethics:
Many Ax-4 experiments (e.g., with human cells, tardigrades, or astronaut data) are subject to strict ethical reviews aboard the ISS.
These reviews ensure astronaut privacy and biocontainment standards are upheld.
As an ISRO-linked Indian astronaut participates in such missions, India must align with ISS norms and potentially develop its own “space biology” ethics framework for future missions.
Q:What is Axiom‑4 (Ax‑4)?
A:The fourth commercial crew mission by Axiom Space, launched on June 25, 2025 aboard a SpaceX Falcon 9 carrying a Crew Dragon capsule to the ISS.
Q:Who is the first Indian on the ISS?
A:Group Captain Shubhanshu Shukla becomes India’s first astronaut to visit the ISS on Ax‑4; Rakesh Sharma (1984) flew on a Soviet Soyuz, not the ISS.
Q:What spacecraft and rocket are used in Ax‑4?
A:A Crew Dragon capsule (Endeavour) launched by a reused SpaceX Falcon 9 rocket—part of broader SpaceX launches that include Falcon Heavy missions.
Q:What experiments are onboard Ax‑4?
A:Around 60 experiments from 31 countries, including Indian payloads in microgravity biology, biotechnology, cognitive testing, and tardigrade resilience.
The Axiom 4 (aka Ax‑4) mission marks a defining moment for India’s return to human spaceflight—this time aboard a Crew Dragon on a Falcon 9 launch via SpaceX launches in partnership with Axiom Space. It builds on India’s legacy from Rakesh Sharma’s Soviet-era flight and positions the nation firmly within the global commercial space landscape. Ax‑4 equips India with vital experience in licensing, liability, insurance, and space bioethics, readying the country for its indigenous LVM3 Crew missions and an eventual Indian station. With strong policy backing—through the 2023 Space Policy and relaxed FDI norms—India is poised to transition from being a government-led space actor to a vibrant player in private-sector human spaceflight and space tourism.
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